Clinicopathological correlation of outer retinal tubulation in age-related macular degeneration.

نویسندگان

  • Katie M Litts
  • Jeffrey D Messinger
  • Kara Dellatorre
  • Lawrence A Yannuzzi
  • K Bailey Freund
  • Christine A Curcio
چکیده

Wilmette, IL—Pediatric Eye Associates (3/1):Deborah R. Fishman (I), JoAnn Spieker (C), Aliza Julian (E); Portland, OR—Casey Eye Institute (3/0):Daniel J. Karr (I), Allison I. Summers (I), Paula K. Rauch (C), YelenaM. Bubnoz (E), Albert Romo (E); Columbus, OH—The Ohio State University (3/0):Marjean T. Kulp (I), Freda D. Dallas (C); Portland, OR—Pacific University College of Optometry (3/2): Richard London (I), James J. Kundart (I), Jayne L. Silver (C), TonyaM. Tira (E); Kansas City, MO—Children’s Mercy Hospitals and Clinics (3/1): Amy L. Langford (I), Rebecca J. Dent (C), Amy R. Sullivan (E); San Francisco, CA—University of California, San Francisco Department of Ophthalmology (3/1):* Tina Rutar (I), Alejandra de Alba Campomanes (I), Patricia W. Tam (C); Silverdale, WA—Jason C. Cheung, M.D., PS (3/1):Melissa L. Rice (I), Jason C. Cheung (I), Tiffany M. Parypa (C), Jacque J. Ferro (E), Andria E. Goddard (E); Salt Lake City, UT—University of Utah Health Care, Moran Eye Center (2/1): Robert O. Hoffman (I), Marielle P. Young (I), Scott A. Larson (I), Elisa M. Robertson (C), Jason K. Taylor (E); Philadelphia, PA—Salus University/Pennsylvania College of Optometry (2/1): Mitchell M. Scheiman (I), Karen E. Pollack (C), Elise B. Ciner (E);Marlton, NJ— Michael F. Gallaway, O.D. (2/1):Michael F. Gallaway (I), Debbie L. Killion (C), Beth Zlock (E); Bloomington, IN—Indiana University School of Optometry (2/1):DonW. Lyon (I), Vivian M.Wong (I), Kristy M. Dunlap (C), Tawna L. Roberts (E); Lincoln, NE—Eye Surgical Associates (2/1):Donald P. Sauberan (I), Jody C. Hemberger (C), Gail Walker (E), Jenni A. Craf, (E); Chattanooga, TN—Pediatric Eye Specialists (2/0): Edward A. Petersen (I), Zachary S. McCarty (I), Charla H. Petersen (C), Amie Jenkins (E); Boston, MA—Harvard Vanguard Medical Associates (2/1): Justin B. Smith (I), Mei L. Mellott (I), Troy L. Kieser (C), Kate A. Palitsch (E); Baltimore, MD—Wilmer Ophthalmological Institute, John Hopkins University (1/0):*Michael X. Repka (I), Alex Christoff (C), Xiaonong Liu (C), Carole R. Goodman (E); Calgary, Alberta, Canada—Alberta Children’s Hospital (1/1): William F. Astle (I), Emi N. Sanders (C), Heather N. Sandusky (E); Rochester, MN—Mayo Clinic (1/1):* JonathanM. Holmes (I), Tomohiko Yamada (I), Rebecca A. Nielsen (C), Debbie M. Priebe (E), Janet L. Westergaard (E); St. Louis, MO—St. Louis Children’s Hospital Eye Center (1/1): James R. Hoekel (I), Marlo L. Galli (C), Tracey Fast (E); Grand Rapids, MI—Pediatric Ophthalmology, P.C. (1/1): Patrick J. Droste (I), Robert J. Peters (I), Jan Hilbrands (C), Misha K. Mennega (E); Chicago IL—Illinois College of Optometry (1/1): Yi Pang (I), Megan Allen (I), Anesu H. Mvududu (C); Albuquerque, NM—Children’s Eye Center of NewMexico (1/1): Todd A. Goldblum (I), Angela Alfaro (C), Chastity R. Escobedo (E);Wilmington, DE— Delaware Vision Academy, L.L.C. (1/1):Don D. Blackburn (I), Tracy Tunis (C), Florence Greene (E);Wilmington, NC—Eye Associates of Wilington, P.A. (1/1): David A. Johnson (I), Kelly L. Moulton (C), Kellie Drake (E);NewHaven, CT—Yale School of Medicine, Department of Ophthalmology and Visual Science (1/1): Jennifer A. Galvin (I), Daniel J. Salchow (I), Margaret B. Therriault (C).

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منابع مشابه

OUTER RETINAL TUBULATION IN ADVANCED AGE-RELATED MACULAR DEGENERATION: Optical Coherence Tomographic Findings Correspond to Histology.

PURPOSE To compare optical coherence tomography (OCT) and histology of outer retinal tubulation (ORT) secondary to advanced age-related macular degeneration in patients and in postmortem specimens, with particular attention to the basis of the hyperreflective border of ORT. METHOD A private referral practice (imaging) and an academic research laboratory (histology) collaborated on two retrosp...

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Inner Segment Remodeling and Mitochondrial Translocation in Cone Photoreceptors in Age-Related Macular Degeneration With Outer Retinal Tubulation.

PURPOSE To quantify impressions of mitochondrial translocation in degenerating cones and to determine the nature of accumulated material in the subretinal space with apparent inner segment (IS)-like features by examining cone IS ultrastructure. METHODS Human donor eyes with advanced age-related macular degeneration (AMD) were screened for outer retinal tubulation (ORT) in macula-wide, high-re...

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Outer retinal tubulation: a novel optical coherence tomography finding.

OBJECTIVE To describe tubular structures found in the outer retina seen in a variety of retinal disorders. METHODS Sixty-nine eyes of 63 patients were examined with spectral-domain optical coherence tomography. Optical coherence tomography C-scans were correlated with their corresponding B-scans. The prevalence, number, size, and shape of the tubular structures were determined. RESULTS Bran...

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Outer retinal tubulation analysis in cases of macular dystrophy.

Macular dystrophies are a heterogeneous group of diseases characterized either by retina pigment epithelium (RPE) atrophy or by the deposit of substances –mainly lipofuscin above or below the RPE. Outer retinal tubulation (ORT) was described recently in tomographic images as pseudo-cystic spaces surrounded by a hyper-reflective wall located in the outer retinal layers.1,2 We have analyzed the p...

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Cell based therapies in retinal diseases

Background Degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. The principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. To briefly review the lines of research and potential candidates for cell based therapies among ...

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The occurrence and progression of outer retinal tubulation in Chinese patients after intravitreal injections of ranibizumab

To investigate the occurrence and progression of outer retinal tubulation (ORT) in Chinese patients after intravitreal ranibizumab injections, using spectral domain optical coherence tomography (SD-OCT) with eye tracking function. 15 age related macular degeneration (AMD) and 6 polypoidal choroidal vasculopathy (PCV) eyes of 21 patients were enrolled and assessed by SD-OCT. One patient received...

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عنوان ژورنال:
  • JAMA ophthalmology

دوره 133 5  شماره 

صفحات  -

تاریخ انتشار 2015